QT Dispersion in Anorexia Nervosa

We read with interest Roche and colleagues’ article1 demonstrating normalization of QT dynamicity and measures of heart rate variability (HRV) with refeeding in anorexia nervosa (AN). We previously observed a more than twofold increase in QT dispersion in patients with chronic anorexia nervosa compared with age-matched controls.2 In addition, our data suggest that patients with AN with a low metabolic rate at rest, at their nadir weight, appear to be at greater risk for increased QT dispersion. Roche and colleagues also noted a lack of QT prolongation among their 10 subjects, which we and other authors2,3 previously demonstrated.

1. Mehler PS, Krantz MJ. QT Dispersion in Anorexia Nervosa. American Journal of Cardiology 96(7):1034, 2005. (Ltr) | https://www.ajconline.org/article/S0002-9149(05)00552-7/abstract