Generous grants and research funding from a variety of sources allows Denver Health to operate a successful safety net healthcare system. Some current funding agencies include:

American College of Surgeons

Agency for Healthcare Research and Quality

American Legacy Foundation

Bureau of Primary Health Care

Centers for Disease Control

Colorado Community Health Network

Colorado Department of Public Health and Environment

Colorado Trust

Health Resources and Services Administration

Kellogg Foundation

Mayor's Office of HIV Resources

National Institute of Allergy and Infectious Diseases

National Institute of Child Health and Human Development

National Institute of Diabetes & Digestive & Kidney Diseases

National Institutes of Health

Piton Foundation

Robert Wood Johnson Foundation

Substance Abuse and Mental Health Services Administration

University of Colorado Health Sciences Center

University of Pennsylvania